Title : Activation of peroxisome proliferator-activated receptor-{delta} by GW501516 prevents fatty acid-induced nuclear factor-{kappa}B activation and insulin resistance in skeletal muscle cells.

Pub. Date : 2010 Apr

PMID : 20185762






1 Functional Relationships(s)
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1 In C2C12 skeletal muscle cells, the PPARdelta agonist GW501516 prevented phosphorylation of insulin receptor substrate-1 at Ser(307) and the inhibition of insulin-stimulated Akt phosphorylation caused by exposure to the saturated fatty acid palmitate. saturated fatty acid palmitate peroxisome proliferator activator receptor delta Mus musculus