Title : Cross-talk between bradykinin and epidermal growth factor in regulating IL-6 production in human airway smooth muscle cells.

Pub. Date : 2010 Jan-Feb

PMID : 20184800






3 Functional Relationships(s)
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1 Moreover, AG-1478 (2 microM), reduced BK-induced IL-6 secretion by 28% and abrogated the synergic induction of IL-6 induced by BK plus EGF (from 8312 +/- 1267 to 3229 +/- 597 pg/ml, n = 5, p < 0.05). RTKI cpd interleukin 6 Homo sapiens
2 Moreover, AG-1478 (2 microM), reduced BK-induced IL-6 secretion by 28% and abrogated the synergic induction of IL-6 induced by BK plus EGF (from 8312 +/- 1267 to 3229 +/- 597 pg/ml, n = 5, p < 0.05). RTKI cpd interleukin 6 Homo sapiens
3 AG-1478 dual effects on IL-6 secretion induced by BK alone or BK plus EGF were also observed in cells treated with genistein, a tyrosine kinase inhibitor, and AG-825, an ErbB-2 inhibitor. RTKI cpd interleukin 6 Homo sapiens