Title : Alpha-lipoic acid inhibits hepatic PAI-1 expression and fibrosis by inhibiting the TGF-beta signaling pathway.

Pub. Date : 2010 Mar 12

PMID : 20153726






1 Functional Relationships(s)
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1 The results of the present study indicate that ALA inhibits hepatic PAI-1 expression through inhibition of TGF-beta-mediated molecular mediators, including Smad3, AP1, and Sp1, and prevents the development of BDL-induced hepatic fibrosis. Thioctic Acid jun proto-oncogene Mus musculus