Pub. Date : 2010 Mar 10
PMID : 20151649
6 Functional Relationships(s)Download |
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Sentence | Compound Name | Protein Name | Organism |
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| 1 | Gallic acid induces apoptosis of lung fibroblasts via a reactive oxygen species-dependent ataxia telangiectasia mutated-p53 activation pathway. | Gallic Acid | ataxia telangiectasia mutated | Mus musculus | ||
| 2 | Mechanistic studies showed that gallic acid induces early phosphorylation of p53(Ser18) and histone 2AX(Ser139) (H2AX) via ataxia telangiectasia mutated (ATM) activation in response to ROS-provoked DNA damage. | Gallic Acid | ataxia telangiectasia mutated | Mus musculus | ||
| 3 | Mechanistic studies showed that gallic acid induces early phosphorylation of p53(Ser18) and histone 2AX(Ser139) (H2AX) via ataxia telangiectasia mutated (ATM) activation in response to ROS-provoked DNA damage. | Gallic Acid | ataxia telangiectasia mutated | Mus musculus | ||
| 4 | When mouse lung fibroblasts were treated with caffeine, an ATM kinase inhibitor, the levels of p53, phosphorylated p53(Ser18), and cell death induced by gallic acid were significantly attenuated. | Gallic Acid | ataxia telangiectasia mutated | Mus musculus | ||
| 5 | Additionally, pretreatment with antioxidants drastically inhibited the gallic acid-induced 8-hydroxy-2"-deoxyguanosine (8-OH-dG) formation and phosphorylation of p53(Ser18) and ATM(Ser1981), as well as apoptosis. | Gallic Acid | ataxia telangiectasia mutated | Mus musculus | ||
| 6 | Our results provide the first evidence of the activation of ROS-dependent ATM/p53 signaling as a critical mechanism of gallic acid-induced cell death in primary cultured mouse lung fibroblasts. | Gallic Acid | ataxia telangiectasia mutated | Mus musculus | ||