Title : Altered ion channel formation by the Parkinson's-disease-linked E46K mutant of alpha-synuclein is corrected by GM3 but not by GM1 gangliosides.

Pub. Date : 2010 Mar 19

PMID : 20114052






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The alpha-syn mutant E46K has a stronger affinity for GM3 than the wild-type protein, and the interaction is inhibited by 3"-sialyllactose (the glycone part of GM3). glycone synuclein alpha Homo sapiens