PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20091056-5 2010 It also highlights the key role in tacrolimus pharmacokinetics of the CYP3A system and P-gp polymorphisms, and their influence in high-risk situations when enzyme activity is already affected by enterocyte damage due to diarrhoea and CCB competition. Tacrolimus 35-45 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 70-75