Pub. Date : 2010 Mar
PMID : 20088787
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Ras-induced resistance to lapatinib is overcome by MEK inhibition. | Lapatinib | mitogen-activated protein kinase kinase 7 | Homo sapiens |
| 2 | Importantly, we found that resistance to lapatinib due to ras overexpression or to ras V12 is overcome by MEK inhibition with U0126, suggesting a key role for the MEK-Erk pathway in ras-induced resistance. | Lapatinib | mitogen-activated protein kinase kinase 7 | Homo sapiens |
| 3 | Importantly, we found that resistance to lapatinib due to ras overexpression or to ras V12 is overcome by MEK inhibition with U0126, suggesting a key role for the MEK-Erk pathway in ras-induced resistance. | Lapatinib | mitogen-activated protein kinase kinase 7 | Homo sapiens |
| 4 | Combining MEK inhibitors with lapatinib may help overcome this form of resistance and increase the efficacy of lapatinib in these tumors. | Lapatinib | mitogen-activated protein kinase kinase 7 | Homo sapiens |