PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20088787-0	2010	Ras-induced resistance to lapatinib is overcome by MEK inhibition.	Lapatinib	26-35	mitogen-activated protein kinase kinase 7	Homo sapiens	51-54	
20088787-6	2010	Importantly, we found that resistance to lapatinib due to ras overexpression or to ras V12 is overcome by MEK inhibition with U0126, suggesting a key role for the MEK-Erk pathway in ras-induced resistance.	Lapatinib	41-50	mitogen-activated protein kinase kinase 7	Homo sapiens	106-109	
20088787-6	2010	Importantly, we found that resistance to lapatinib due to ras overexpression or to ras V12 is overcome by MEK inhibition with U0126, suggesting a key role for the MEK-Erk pathway in ras-induced resistance.	Lapatinib	41-50	mitogen-activated protein kinase kinase 7	Homo sapiens	163-166	
20088787-9	2010	Combining MEK inhibitors with lapatinib may help overcome this form of resistance and increase the efficacy of lapatinib in these tumors.	Lapatinib	111-120	mitogen-activated protein kinase kinase 7	Homo sapiens	10-13