Pub. Date : 2010 Apr 15
PMID : 20083195
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Celecoxib activates PI-3K/Akt and mitochondrial redox signaling to enhance heme oxygenase-1-mediated anti-inflammatory activity in vascular endothelium. | Celecoxib | heme oxygenase 1 | Homo sapiens |
| 2 | This led us to the hypothesis that celecoxib induces the vasculoprotective enzyme heme oxygenase-1 (HO-1). | Celecoxib | heme oxygenase 1 | Homo sapiens |
| 3 | This led us to the hypothesis that celecoxib induces the vasculoprotective enzyme heme oxygenase-1 (HO-1). | Celecoxib | heme oxygenase 1 | Homo sapiens |
| 4 | In human umbilical vein and aortic endothelial cells, 24-48 h treatment with celecoxib induced HO-1 mRNA and protein expression and increased HO-1 enzyme activity. | Celecoxib | heme oxygenase 1 | Homo sapiens |
| 5 | In human umbilical vein and aortic endothelial cells, 24-48 h treatment with celecoxib induced HO-1 mRNA and protein expression and increased HO-1 enzyme activity. | Celecoxib | heme oxygenase 1 | Homo sapiens |
| 6 | Furthermore, celecoxib-induced HO-1 was inhibited by dominant-negative Nrf2. | Celecoxib | heme oxygenase 1 | Homo sapiens |
| 7 | The functional significance of HO-1 induction was revealed by celecoxib-mediated inhibition of VCAM-1 expression, a response reversed by the HO-1 antagonist zinc protoporphyrin. | Celecoxib | heme oxygenase 1 | Homo sapiens |
| 8 | The functional significance of HO-1 induction was revealed by celecoxib-mediated inhibition of VCAM-1 expression, a response reversed by the HO-1 antagonist zinc protoporphyrin. | Celecoxib | heme oxygenase 1 | Homo sapiens |
| 9 | HO-1 induction provides a molecular mechanism for clinical observations indicating relative freedom from atherothrombotic complications in patients taking celecoxib compared to other NSAIDs with comparable anti-inflammatory activity. | Celecoxib | heme oxygenase 1 | Homo sapiens |