Pub. Date : 2010 Apr
PMID : 20079464
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Nicotine induces cyclooxygenase-2 and prostaglandin E(2) expression in human umbilical vein endothelial cells. | Nicotine | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 2 | Nicotine treatment increased the expressions of COX-2 at mRNA and protein level in a dose-dependent manner, following prostaglandin E(2) (PGE(2)) release enhancement. | Nicotine | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 3 | Pyrrolidine dithiocarbamate (PDTC, NF-kappaB inhibitor) and alpha-Bungarotoxin (alpha-Btx, nicotinic acetylcholine receptor antagonist) attenuated the nicotine-induced COX-2 expression and PGE(2) production. | Nicotine | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 4 | Furthermore, nicotine-induced ICAM-1 expression was reduced by NS-398 (selective COX-2 inhibitor). | Nicotine | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 5 | Taken together, the present study demonstrated that nicotine-induced COX-2 expression through NF-kappaB activation which mediated by nicotinic acetylcholine receptor and the induction of COX-2 was related to ICAM-1 expression. | Nicotine | prostaglandin-endoperoxide synthase 2 | Homo sapiens |
| 6 | Taken together, the present study demonstrated that nicotine-induced COX-2 expression through NF-kappaB activation which mediated by nicotinic acetylcholine receptor and the induction of COX-2 was related to ICAM-1 expression. | Nicotine | prostaglandin-endoperoxide synthase 2 | Homo sapiens |