PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20079464-0	2010	Nicotine induces cyclooxygenase-2 and prostaglandin E(2) expression in human umbilical vein endothelial cells.	Nicotine	0-8	prostaglandin-endoperoxide synthase 2	Homo sapiens	17-33	
20079464-3	2010	Nicotine treatment increased the expressions of COX-2 at mRNA and protein level in a dose-dependent manner, following prostaglandin E(2) (PGE(2)) release enhancement.	Nicotine	0-8	prostaglandin-endoperoxide synthase 2	Homo sapiens	48-53	
20079464-4	2010	Pyrrolidine dithiocarbamate (PDTC, NF-kappaB inhibitor) and alpha-Bungarotoxin (alpha-Btx, nicotinic acetylcholine receptor antagonist) attenuated the nicotine-induced COX-2 expression and PGE(2) production.	Nicotine	151-159	prostaglandin-endoperoxide synthase 2	Homo sapiens	168-173	
20079464-5	2010	Furthermore, nicotine-induced ICAM-1 expression was reduced by NS-398 (selective COX-2 inhibitor).	Nicotine	13-21	prostaglandin-endoperoxide synthase 2	Homo sapiens	81-86	
20079464-6	2010	Taken together, the present study demonstrated that nicotine-induced COX-2 expression through NF-kappaB activation which mediated by nicotinic acetylcholine receptor and the induction of COX-2 was related to ICAM-1 expression.	Nicotine	52-60	prostaglandin-endoperoxide synthase 2	Homo sapiens	69-74	
20079464-6	2010	Taken together, the present study demonstrated that nicotine-induced COX-2 expression through NF-kappaB activation which mediated by nicotinic acetylcholine receptor and the induction of COX-2 was related to ICAM-1 expression.	Nicotine	52-60	prostaglandin-endoperoxide synthase 2	Homo sapiens	187-192