Title : Down-regulation of the LXR transcriptome provides the requisite cholesterol levels to proliferating hepatocytes.

Pub. Date : 2010 Apr

PMID : 20044803






2 Functional Relationships(s)
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Protein Name
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1 In physiological conditions, high intracellular cholesterol levels cause increased synthesis of oxysterols, which activate LXR, thus triggering a transcriptional response for cholesterol secretion and catabolism. Oxysterols nuclear receptor subfamily 1, group H, member 3 Mus musculus
2 The inactivation of LXR following PH is related to the reduced oxysterol availability by way of decreased synthesis, and increased sulfation and secretion. Oxysterols nuclear receptor subfamily 1, group H, member 3 Mus musculus