Pub. Date : 2010 Apr
PMID : 20043997
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In adrenal steroidogenesis, CYP17 catalyses the 17alpha-hydroxylation of pregnenolone and progesterone and the subsequent 17,20-lyase reaction, yielding adrenal androgens. | Progesterone | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |
| 2 | CYP17 has also been shown to exhibit 16alpha-hydroxylase activity towards progesterone in some species, with only human and chimp CYP17 catalysing the biosynthesis of substantial amounts of 16-OHprogesterone. | Progesterone | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |
| 3 | Wt human CYP17 converted approximately 30% progesterone to 16-OHprogesterone while the Ala105Leu mutant converted negligible amounts to 16-OHprogesterone ( approximately 9%), comparable to wt CYP17 of the other three species when expressed in COS-1 cells. | Progesterone | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |