Title : Curcumin protects against hepatic and renal injuries mediated by inducible nitric oxide synthase during selenium-induced toxicity in Wistar rats.

Pub. Date : 2010 Jun

PMID : 20025056






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1 Curcumin protects against hepatic and renal injuries mediated by inducible nitric oxide synthase during selenium-induced toxicity in Wistar rats. Curcumin nitric oxide synthase 2 Rattus norvegicus
2 To understand the probable mechanism of action of curcumin, we analyzed inducible nitric oxide synthase (iNOS) expression by immunohistochemistry, and the results showed an increased iNOS expression in selenium-alone induced liver and kidney. Curcumin nitric oxide synthase 2 Rattus norvegicus
3 To understand the probable mechanism of action of curcumin, we analyzed inducible nitric oxide synthase (iNOS) expression by immunohistochemistry, and the results showed an increased iNOS expression in selenium-alone induced liver and kidney. Curcumin nitric oxide synthase 2 Rattus norvegicus
4 Such high iNOS levels were inhibited in liver and kidney of rats pretreated with curcumin and then with selenium 24 h later. Curcumin nitric oxide synthase 2 Rattus norvegicus
5 Based on the histological results, it can be concluded that curcumin functions as a protective agent against selenium-induced toxicity in liver as well as kidney, and this action is probably by the regulatory role of curcumin on iNOS expression. Curcumin nitric oxide synthase 2 Rattus norvegicus
6 Based on the histological results, it can be concluded that curcumin functions as a protective agent against selenium-induced toxicity in liver as well as kidney, and this action is probably by the regulatory role of curcumin on iNOS expression. Curcumin nitric oxide synthase 2 Rattus norvegicus