Title : Nuclear EGFR is required for cisplatin resistance and DNA repair.

Pub. Date : 2009 Mar 8

PMID : 19956435






7 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Nuclear EGFR is required for cisplatin resistance and DNA repair. Cisplatin epidermal growth factor receptor Homo sapiens
2 Recently, it has been shown that the DNA damage-inducing agents ionizing radiation (IR) and cisplatin are able to induce EGFR nuclear localization, and this nuclear localization is correlated with increased DNA-PK activity, which plays an essential role in DNA double stranded repair. Cisplatin epidermal growth factor receptor Homo sapiens
3 We found that mutation in the nuclear localization signal (NLS) of EGFR (mNLS), known to be unable to translocate to the nucleus, released EGFR induced resistance to cisplatin. Cisplatin epidermal growth factor receptor Homo sapiens
4 We found that mutation in the nuclear localization signal (NLS) of EGFR (mNLS), known to be unable to translocate to the nucleus, released EGFR induced resistance to cisplatin. Cisplatin epidermal growth factor receptor Homo sapiens
5 In addition, we show that the re-expression of a functional nuclear localization sequence in EGFR (mNLS-R) is not only able to restore its resistance to cisplatin, but also reduced the DNA damage caused by cisplatin, and restored DNA repair activity. Cisplatin epidermal growth factor receptor Homo sapiens
6 In addition, we show that the re-expression of a functional nuclear localization sequence in EGFR (mNLS-R) is not only able to restore its resistance to cisplatin, but also reduced the DNA damage caused by cisplatin, and restored DNA repair activity. Cisplatin epidermal growth factor receptor Homo sapiens
7 Thus, we demonstrate here that nuclear EGFR is required for DNA repair and resistance to cisplatin treatment. Cisplatin epidermal growth factor receptor Homo sapiens