Pub. Date : 2009 Mar 8
PMID : 19956435
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Nuclear EGFR is required for cisplatin resistance and DNA repair. | Cisplatin | epidermal growth factor receptor | Homo sapiens |
| 2 | Recently, it has been shown that the DNA damage-inducing agents ionizing radiation (IR) and cisplatin are able to induce EGFR nuclear localization, and this nuclear localization is correlated with increased DNA-PK activity, which plays an essential role in DNA double stranded repair. | Cisplatin | epidermal growth factor receptor | Homo sapiens |
| 3 | We found that mutation in the nuclear localization signal (NLS) of EGFR (mNLS), known to be unable to translocate to the nucleus, released EGFR induced resistance to cisplatin. | Cisplatin | epidermal growth factor receptor | Homo sapiens |
| 4 | We found that mutation in the nuclear localization signal (NLS) of EGFR (mNLS), known to be unable to translocate to the nucleus, released EGFR induced resistance to cisplatin. | Cisplatin | epidermal growth factor receptor | Homo sapiens |
| 5 | In addition, we show that the re-expression of a functional nuclear localization sequence in EGFR (mNLS-R) is not only able to restore its resistance to cisplatin, but also reduced the DNA damage caused by cisplatin, and restored DNA repair activity. | Cisplatin | epidermal growth factor receptor | Homo sapiens |
| 6 | In addition, we show that the re-expression of a functional nuclear localization sequence in EGFR (mNLS-R) is not only able to restore its resistance to cisplatin, but also reduced the DNA damage caused by cisplatin, and restored DNA repair activity. | Cisplatin | epidermal growth factor receptor | Homo sapiens |
| 7 | Thus, we demonstrate here that nuclear EGFR is required for DNA repair and resistance to cisplatin treatment. | Cisplatin | epidermal growth factor receptor | Homo sapiens |