Pub. Date : 2009 Oct 27
PMID : 19855246
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | : As part of a phase 1 clinical trial, we investigated the effect of CP-690,550 after 29 days of 30 mg twice daily treatment at the cellular level in eight kidney transplant patients by studying ex vivo phosphorylation of STAT5 (P-STAT5), the key substrate of JAK3. | tofacitinib | signal transducer and activator of transcription 5A | Homo sapiens |
| 2 | At the functional level, the inhibitory effect of CP-690,550 was confirmed by determining the expression of several STAT5 targets genes. | tofacitinib | signal transducer and activator of transcription 5A | Homo sapiens |
| 3 | : Analysis of P-STAT5 may, therefore, be used to determine the immunomodulatory effect of CP-690,550 at the cellular level in transplant patients. | tofacitinib | signal transducer and activator of transcription 5A | Homo sapiens |