Pub. Date : 1990 Nov-Dec
PMID : 1981505
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Quinolone inhibition of cytochrome P-450-dependent caffeine metabolism in human liver microsomes. | Caffeine | cytochrome P450 family 4 subfamily F member 3 | Homo sapiens |
| 2 | The results indicate that the reduction of caffeine clearance by concomitant quinolone application observed in vivo is primarily due to a competitive interaction of the inhibiting quinolones with the cytochrome P-450 isoenzyme(s) mediating caffeine demethylation. | Caffeine | cytochrome P450 family 4 subfamily F member 3 | Homo sapiens |
| 3 | The results indicate that the reduction of caffeine clearance by concomitant quinolone application observed in vivo is primarily due to a competitive interaction of the inhibiting quinolones with the cytochrome P-450 isoenzyme(s) mediating caffeine demethylation. | Caffeine | cytochrome P450 family 4 subfamily F member 3 | Homo sapiens |