Pub. Date : 2010 Apr
PMID : 19766402
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Regulation of cortical and hippocampal 5-HT(1A) receptor function by corticosterone in GR+/- mice. | Corticosterone | 5-hydroxytryptamine (serotonin) receptor 1A | Mus musculus |
| 2 | Corticosterone treatment (10mg/kg, sc once daily for 21 days) of wild-type mice resulted in a decrease in 5-HT(1A) receptor function in prefrontal cortex [8-OH-DPAT-stimulated [(35)S]GTPgammaS binding (% above basal), vehicle-treated: 39+/-4.9; corticosterone-treated: 17+/-2.8], but not in hippocampus. | Corticosterone | 5-hydroxytryptamine (serotonin) receptor 1A | Mus musculus |
| 3 | Corticosterone treatment (10mg/kg, sc once daily for 21 days) of wild-type mice resulted in a decrease in 5-HT(1A) receptor function in prefrontal cortex [8-OH-DPAT-stimulated [(35)S]GTPgammaS binding (% above basal), vehicle-treated: 39+/-4.9; corticosterone-treated: 17+/-2.8], but not in hippocampus. | Corticosterone | 5-hydroxytryptamine (serotonin) receptor 1A | Mus musculus |
| 4 | The constitutive reduction in GR expression prevented the down-regulation of 5-HT(1A) receptor function in frontal cortex by chronic corticosterone administration. | Corticosterone | 5-hydroxytryptamine (serotonin) receptor 1A | Mus musculus |
| 5 | In contrast, corticosterone treatment of GR+/- mice resulted in an increase in 5-HT(1A) receptor function in hippocampus which reached statistical significance in CA2/3 region [8-OH-DPAT-stimulated [(35)S]GTPgammaS binding (% above basal), vehicle-treated: 41+/-9.7; corticosterone-treated: 94+/-23]. | Corticosterone | 5-hydroxytryptamine (serotonin) receptor 1A | Mus musculus |
| 6 | In contrast, corticosterone treatment of GR+/- mice resulted in an increase in 5-HT(1A) receptor function in hippocampus which reached statistical significance in CA2/3 region [8-OH-DPAT-stimulated [(35)S]GTPgammaS binding (% above basal), vehicle-treated: 41+/-9.7; corticosterone-treated: 94+/-23]. | Corticosterone | 5-hydroxytryptamine (serotonin) receptor 1A | Mus musculus |
| 7 | Although GR+/- mice do not exhibit changes in baseline corticosterone, the constitutive deficiency in GR appears to have unmasked regulatory effects of elevated corticosterone in the maintenance of 5-HT(1A) receptor function in prefrontal cortex and hippocampus. | Corticosterone | 5-hydroxytryptamine (serotonin) receptor 1A | Mus musculus |