PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19766402-0 2010 Regulation of cortical and hippocampal 5-HT(1A) receptor function by corticosterone in GR+/- mice. Corticosterone 69-83 5-hydroxytryptamine (serotonin) receptor 1A Mus musculus 39-56 19766402-5 2010 Corticosterone treatment (10mg/kg, sc once daily for 21 days) of wild-type mice resulted in a decrease in 5-HT(1A) receptor function in prefrontal cortex [8-OH-DPAT-stimulated [(35)S]GTPgammaS binding (% above basal), vehicle-treated: 39+/-4.9; corticosterone-treated: 17+/-2.8], but not in hippocampus. Corticosterone 0-14 5-hydroxytryptamine (serotonin) receptor 1A Mus musculus 106-123 19766402-5 2010 Corticosterone treatment (10mg/kg, sc once daily for 21 days) of wild-type mice resulted in a decrease in 5-HT(1A) receptor function in prefrontal cortex [8-OH-DPAT-stimulated [(35)S]GTPgammaS binding (% above basal), vehicle-treated: 39+/-4.9; corticosterone-treated: 17+/-2.8], but not in hippocampus. Corticosterone 245-259 5-hydroxytryptamine (serotonin) receptor 1A Mus musculus 106-123 19766402-6 2010 The constitutive reduction in GR expression prevented the down-regulation of 5-HT(1A) receptor function in frontal cortex by chronic corticosterone administration. Corticosterone 133-147 5-hydroxytryptamine (serotonin) receptor 1A Mus musculus 77-94 19766402-7 2010 In contrast, corticosterone treatment of GR+/- mice resulted in an increase in 5-HT(1A) receptor function in hippocampus which reached statistical significance in CA2/3 region [8-OH-DPAT-stimulated [(35)S]GTPgammaS binding (% above basal), vehicle-treated: 41+/-9.7; corticosterone-treated: 94+/-23]. Corticosterone 13-27 5-hydroxytryptamine (serotonin) receptor 1A Mus musculus 79-96 19766402-7 2010 In contrast, corticosterone treatment of GR+/- mice resulted in an increase in 5-HT(1A) receptor function in hippocampus which reached statistical significance in CA2/3 region [8-OH-DPAT-stimulated [(35)S]GTPgammaS binding (% above basal), vehicle-treated: 41+/-9.7; corticosterone-treated: 94+/-23]. Corticosterone 267-281 5-hydroxytryptamine (serotonin) receptor 1A Mus musculus 79-96 19766402-9 2010 Although GR+/- mice do not exhibit changes in baseline corticosterone, the constitutive deficiency in GR appears to have unmasked regulatory effects of elevated corticosterone in the maintenance of 5-HT(1A) receptor function in prefrontal cortex and hippocampus. Corticosterone 161-175 5-hydroxytryptamine (serotonin) receptor 1A Mus musculus 198-215