Title : [Reversal effect and mechanism of lobeline on the multidrug-resistance of human breast cancer cells MCF-7/ADM].

Pub. Date : 2009 Aug

PMID : 19734580






3 Functional Relationships(s)
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1 Fluorospectorphotometer was employed to investigate the intracellular concentration of rhodamine123 to reflect the effect of lobeline on the activity of MDR-related protein P-glycoprotein (P-gp). Lobeline ATP binding cassette subfamily B member 1 Homo sapiens
2 Fluorospectorphotometer was employed to investigate the intracellular concentration of rhodamine123 to reflect the effect of lobeline on the activity of MDR-related protein P-glycoprotein (P-gp). Lobeline ATP binding cassette subfamily B member 1 Homo sapiens
3 CONCLUSION: Lobeline can reverse the MDR of MCF-7/ADM cells by inhibiting the activity of P-glycoprotein. Lobeline ATP binding cassette subfamily B member 1 Homo sapiens