Title : Extracellular PBEF/NAMPT/visfatin activates pro-inflammatory signalling in human vascular smooth muscle cells through nicotinamide phosphoribosyltransferase activity.

Pub. Date : 2009 Nov

PMID : 19727662






2 Functional Relationships(s)
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1 By using the respective ERK 1/2 and NF-kappaB inhibitors, PD98059 and pyrrolidine dithiocarbamate, we established that iNOS induction by ePBEF/NAMPT/visfatin required the consecutive upstream activation of ERK 1/2 and NF-kappaB. pyrrolidine dithiocarbamic acid nicotinamide phosphoribosyltransferase Homo sapiens
2 By using the respective ERK 1/2 and NF-kappaB inhibitors, PD98059 and pyrrolidine dithiocarbamate, we established that iNOS induction by ePBEF/NAMPT/visfatin required the consecutive upstream activation of ERK 1/2 and NF-kappaB. pyrrolidine dithiocarbamic acid nicotinamide phosphoribosyltransferase Homo sapiens