Title : General anesthetic binding to neuronal alpha4beta2 nicotinic acetylcholine receptor and its effects on global dynamics.

Pub. Date : 2009 Sep 17

PMID : 19697903






1 Functional Relationships(s)
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1 Using our published open-channel structure model of alpha4beta2 nAChR, we identified and evaluated six amphiphilic interaction sites for the volatile anesthetic halothane via flexible ligand docking and subsequent 20-ns molecular dynamics simulations. Halothane cholinergic receptor nicotinic alpha 4 subunit Homo sapiens