Title : TLR4-independent and PKR-dependent interleukin 1 receptor antagonist expression upon LPS stimulation.

Pub. Date : 2009

PMID : 19559408






2 Functional Relationships(s)
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1 2-Aminopurine, a pharmacological PKR inhibitor, completely abrogated LPS-induced expression of IL-1rn in TLR4(neg) DCs, suggesting that LPS-induced TLR4-independent expression of IL-1rn might be mediated by PKR pathways. 2-Aminopurine eukaryotic translation initiation factor 2 alpha kinase 2 Homo sapiens
2 2-Aminopurine, a pharmacological PKR inhibitor, completely abrogated LPS-induced expression of IL-1rn in TLR4(neg) DCs, suggesting that LPS-induced TLR4-independent expression of IL-1rn might be mediated by PKR pathways. 2-Aminopurine eukaryotic translation initiation factor 2 alpha kinase 2 Homo sapiens