Pub. Date : 2009 Aug
PMID : 19508427
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The study also shows that homocysteine-dependent NMDA receptor stimulation and resultant Ca2+ influx leads to rapid and sustained phosphorylation of ERK-MAP kinase. | Homocysteine | mitogen-activated protein kinase 1 | Homo sapiens |
| 2 | Inhibition of ERK phosphorylation attenuates homocysteine-mediated neuronal cell death thereby demonstrating that activation of ERK-MAP kinase signaling pathway is an intermediate step that couples homocysteine-mediated NMDA receptor stimulation to neuronal death. | Homocysteine | mitogen-activated protein kinase 1 | Homo sapiens |
| 3 | Inhibition of ERK phosphorylation attenuates homocysteine-mediated neuronal cell death thereby demonstrating that activation of ERK-MAP kinase signaling pathway is an intermediate step that couples homocysteine-mediated NMDA receptor stimulation to neuronal death. | Homocysteine | mitogen-activated protein kinase 1 | Homo sapiens |
| 4 | Inhibition of ERK phosphorylation attenuates homocysteine-mediated neuronal cell death thereby demonstrating that activation of ERK-MAP kinase signaling pathway is an intermediate step that couples homocysteine-mediated NMDA receptor stimulation to neuronal death. | Homocysteine | mitogen-activated protein kinase 1 | Homo sapiens |
| 5 | Inhibition of ERK phosphorylation attenuates homocysteine-mediated neuronal cell death thereby demonstrating that activation of ERK-MAP kinase signaling pathway is an intermediate step that couples homocysteine-mediated NMDA receptor stimulation to neuronal death. | Homocysteine | mitogen-activated protein kinase 1 | Homo sapiens |
| 6 | The findings also show that cAMP response-element binding protein (CREB), a pro-survival transcription factor and a downstream target of ERK, is only transiently activated following homocysteine exposure. | Homocysteine | mitogen-activated protein kinase 1 | Homo sapiens |
| 7 | The sustained activation of ERK but a transient activation of CREB together suggest that exposure to homocysteine initiates a feedback loop that shuts off CREB signaling without affecting ERK phosphorylation and thereby facilitates homocysteine-mediated neurotoxicity. | Homocysteine | mitogen-activated protein kinase 1 | Homo sapiens |
| 8 | The sustained activation of ERK but a transient activation of CREB together suggest that exposure to homocysteine initiates a feedback loop that shuts off CREB signaling without affecting ERK phosphorylation and thereby facilitates homocysteine-mediated neurotoxicity. | Homocysteine | mitogen-activated protein kinase 1 | Homo sapiens |