PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19508427-5	2009	The study also shows that homocysteine-dependent NMDA receptor stimulation and resultant Ca2+ influx leads to rapid and sustained phosphorylation of ERK-MAP kinase.	Homocysteine	26-38	mitogen-activated protein kinase 1	Homo sapiens	149-152	
19508427-6	2009	Inhibition of ERK phosphorylation attenuates homocysteine-mediated neuronal cell death thereby demonstrating that activation of ERK-MAP kinase signaling pathway is an intermediate step that couples homocysteine-mediated NMDA receptor stimulation to neuronal death.	Homocysteine	45-57	mitogen-activated protein kinase 1	Homo sapiens	14-17	
19508427-6	2009	Inhibition of ERK phosphorylation attenuates homocysteine-mediated neuronal cell death thereby demonstrating that activation of ERK-MAP kinase signaling pathway is an intermediate step that couples homocysteine-mediated NMDA receptor stimulation to neuronal death.	Homocysteine	45-57	mitogen-activated protein kinase 1	Homo sapiens	128-131	
19508427-6	2009	Inhibition of ERK phosphorylation attenuates homocysteine-mediated neuronal cell death thereby demonstrating that activation of ERK-MAP kinase signaling pathway is an intermediate step that couples homocysteine-mediated NMDA receptor stimulation to neuronal death.	Homocysteine	198-210	mitogen-activated protein kinase 1	Homo sapiens	14-17	
19508427-6	2009	Inhibition of ERK phosphorylation attenuates homocysteine-mediated neuronal cell death thereby demonstrating that activation of ERK-MAP kinase signaling pathway is an intermediate step that couples homocysteine-mediated NMDA receptor stimulation to neuronal death.	Homocysteine	198-210	mitogen-activated protein kinase 1	Homo sapiens	128-131	
19508427-7	2009	The findings also show that cAMP response-element binding protein (CREB), a pro-survival transcription factor and a downstream target of ERK, is only transiently activated following homocysteine exposure.	Homocysteine	182-194	mitogen-activated protein kinase 1	Homo sapiens	137-140	
19508427-8	2009	The sustained activation of ERK but a transient activation of CREB together suggest that exposure to homocysteine initiates a feedback loop that shuts off CREB signaling without affecting ERK phosphorylation and thereby facilitates homocysteine-mediated neurotoxicity.	Homocysteine	101-113	mitogen-activated protein kinase 1	Homo sapiens	28-31	
19508427-8	2009	The sustained activation of ERK but a transient activation of CREB together suggest that exposure to homocysteine initiates a feedback loop that shuts off CREB signaling without affecting ERK phosphorylation and thereby facilitates homocysteine-mediated neurotoxicity.	Homocysteine	101-113	mitogen-activated protein kinase 1	Homo sapiens	188-191