Pub. Date : 2009 Aug 10
PMID : 19470933
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Selective inhibition of CYP17 with abiraterone acetate is highly active in the treatment of castration-resistant prostate cancer. | Abiraterone Acetate | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |
| 2 | Abiraterone acetate is a potent, selective, and orally available inhibitor of CYP17, the key enzyme in androgen and estrogen biosynthesis. | Abiraterone Acetate | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |
| 3 | CONCLUSION: CYP17 blockade by abiraterone acetate results in declines in PSA and CTC counts and radiologic responses, confirming that CRPC commonly remains hormone driven. | Abiraterone Acetate | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |