Pub. Date : 2009 Jul 30
PMID : 19436050
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In this study, we demonstrate that bortezomib significantly down-regulated IkappaBalpha expression and triggered NF-kappaB activation in MM cell lines and primary tumor cells from MM patients. | Bortezomib | NFKB inhibitor alpha | Homo sapiens |
| 2 | Molecular mechanisms whereby bortezomib induced IkappaBalpha down-regulation were further examined. | Bortezomib | NFKB inhibitor alpha | Homo sapiens |
| 3 | Bortezomib triggered phosphorylation of IkappaB kinase (IKKbeta) and its upstream receptor-interacting protein 2, whereas IKKbeta inhibitor MLN120B blocked bortezomib-induced IkappaBalpha down-regulation and NF-kappaB activation, indicating receptor-interacting protein 2/IKKbeta signaling plays crucial role in bortezomib-induced NF-kappaB activation. | Bortezomib | NFKB inhibitor alpha | Homo sapiens |
| 4 | Bortezomib triggered phosphorylation of IkappaB kinase (IKKbeta) and its upstream receptor-interacting protein 2, whereas IKKbeta inhibitor MLN120B blocked bortezomib-induced IkappaBalpha down-regulation and NF-kappaB activation, indicating receptor-interacting protein 2/IKKbeta signaling plays crucial role in bortezomib-induced NF-kappaB activation. | Bortezomib | NFKB inhibitor alpha | Homo sapiens |