PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19436050-4	2009	In this study, we demonstrate that bortezomib significantly down-regulated IkappaBalpha expression and triggered NF-kappaB activation in MM cell lines and primary tumor cells from MM patients.	Bortezomib	35-45	NFKB inhibitor alpha	Homo sapiens	75-87	
19436050-8	2009	Molecular mechanisms whereby bortezomib induced IkappaBalpha down-regulation were further examined.	Bortezomib	29-39	NFKB inhibitor alpha	Homo sapiens	48-60	
19436050-9	2009	Bortezomib triggered phosphorylation of IkappaB kinase (IKKbeta) and its upstream receptor-interacting protein 2, whereas IKKbeta inhibitor MLN120B blocked bortezomib-induced IkappaBalpha down-regulation and NF-kappaB activation, indicating receptor-interacting protein 2/IKKbeta signaling plays crucial role in bortezomib-induced NF-kappaB activation.	Bortezomib	156-166	NFKB inhibitor alpha	Homo sapiens	175-187	
19436050-9	2009	Bortezomib triggered phosphorylation of IkappaB kinase (IKKbeta) and its upstream receptor-interacting protein 2, whereas IKKbeta inhibitor MLN120B blocked bortezomib-induced IkappaBalpha down-regulation and NF-kappaB activation, indicating receptor-interacting protein 2/IKKbeta signaling plays crucial role in bortezomib-induced NF-kappaB activation.	Bortezomib	312-322	NFKB inhibitor alpha	Homo sapiens	175-187