PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19431189-3 2009 For example, rational design methods have been utilized to adapt anti-thrombin aptamers to function as biosensors by hybridizing an antisense oligonucleotide containing a quencher to the aptamer containing a fluorescent label. Oligonucleotides 142-157 coagulation factor II, thrombin Homo sapiens 70-78 19431189-4 2009 In the presence of thrombin, the binding equilibrium is shifted, the antisense oligonucleotide dissociates, and the beacon lights up. Oligonucleotides 79-94 coagulation factor II, thrombin Homo sapiens 19-27