Pub. Date : 2009 Jun 15
PMID : 19361540
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Activation of ERK and JNK signaling pathways by mycotoxin citrinin in human cells. | Citrinin | mitogen-activated protein kinase 8 | Homo sapiens |
| 2 | The exposure of human embryonic kidney (HEK293) and HeLa cells to CTN resulted in a dose-dependent increase in the phosphorylation of two major mitogen-activated protein kinases (MAPKs), ERK1/2 and JNK. | Citrinin | mitogen-activated protein kinase 8 | Homo sapiens |
| 3 | Furthermore, co-exposure of HEK293 cells to CTN and MAPK pathway inhibitors demonstrated that CTN increased the levels of Gadd45 beta mRNA through ERK1/2 signaling pathway and up-regulated the MMP3 transcripts majorly via JNK pathway. | Citrinin | mitogen-activated protein kinase 8 | Homo sapiens |
| 4 | Our results suggest that CTN positively regulates ERK1/2 and JNK pathways as well as their downstream effectors in human cells; activated MAPK pathways are also involved in CTN-induced apoptosis. | Citrinin | mitogen-activated protein kinase 8 | Homo sapiens |