Pub. Date : 2009 May 1
PMID : 19299583
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis. | NAD | clock circadian regulator | Homo sapiens |
| 2 | Here we report that both the rate-limiting enzyme in mammalian nicotinamide adenine dinucleotide (NAD+) biosynthesis, nicotinamide phosphoribosyltransferase (NAMPT), and levels of NAD+ display circadian oscillations that are regulated by the core clock machinery in mice. | NAD | clock circadian regulator | Homo sapiens |
| 3 | Here we report that both the rate-limiting enzyme in mammalian nicotinamide adenine dinucleotide (NAD+) biosynthesis, nicotinamide phosphoribosyltransferase (NAMPT), and levels of NAD+ display circadian oscillations that are regulated by the core clock machinery in mice. | NAD | clock circadian regulator | Homo sapiens |
| 4 | In turn, the circadian transcription factor CLOCK binds to and up-regulates Nampt, thus completing a feedback loop involving NAMPT/NAD+ and SIRT1/CLOCK:BMAL1. | NAD | clock circadian regulator | Homo sapiens |