Protein Name clock circadian regulator
Organism Homo sapiens
Gene ID 9575
Gene Symbol

CLOCK

UniProt O15516 (CLOCK_HUMAN), Q53EU0 (Q53EU0_HUMAN), Q3ZCT4 (Q3ZCT4_HUMAN)
Relationships Total Number of functionally related compound(s) : 129
Total Number of Articles : 170
Description

clock circadian regulator

Gene Summary

The protein encoded by this gene plays a central role in the regulation of circadian rhythms. The protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and contains DNA binding histone acetyltransferase activity. The encoded protein forms a heterodimer with ARNTL (BMAL1) that binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Polymorphisms in this gene may be associated with behavioral changes in certain populations and with obesity and metabolic syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

synonyms
  • circadian locomoter output cycles protein kaput
  • circadian locomoter output cycles kaput protein
  • class E basic helix-loop-helix protein 8
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Properties