Title : Mechanism of ritonavir changes in methadone pharmacokinetics and pharmacodynamics: II. Ritonavir effects on CYP3A and P-glycoprotein activities.

Pub. Date : 2008 Oct

PMID : 19238656






1 Functional Relationships(s)
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1 Ritonavir diminishes methadone plasma concentrations, an effect attributed to CYP3A induction, but the actual mechanisms are unknown. Methadone cytochrome P450 family 3 subfamily A member 4 Homo sapiens