Pub. Date : 2009 Apr
PMID : 19211828
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Enterolactone inhibits insulin-like growth factor-1 receptor signaling in human prostatic carcinoma PC-3 cells. | 2,3-bis(3'-hydroxybenzyl)butyrolactone | insulin like growth factor 1 receptor | Homo sapiens |
| 2 | At nutritionally relevant concentrations (20-60 micromol/L), enterolactone inhibited IGF-1-induced activation of IGF-1R and its downstream AKT and mitogen-activated protein kinase/extracellular-signal regulated kinase signaling pathways. | 2,3-bis(3'-hydroxybenzyl)butyrolactone | insulin like growth factor 1 receptor | Homo sapiens |
| 3 | Knockdown of IGF-1R by plasmids with siRNA (si) against IGF-1R mRNA resulted in inhibition of proliferation of PC-3 cells and cell numbers did not differ when the si-IGF-1R groups (cells transfected with plasmids containing siRNA against IGF-1R mRNA) were treated or untreated with enterolactone. | 2,3-bis(3'-hydroxybenzyl)butyrolactone | insulin like growth factor 1 receptor | Homo sapiens |
| 4 | Knockdown of IGF-1R by plasmids with siRNA (si) against IGF-1R mRNA resulted in inhibition of proliferation of PC-3 cells and cell numbers did not differ when the si-IGF-1R groups (cells transfected with plasmids containing siRNA against IGF-1R mRNA) were treated or untreated with enterolactone. | 2,3-bis(3'-hydroxybenzyl)butyrolactone | insulin like growth factor 1 receptor | Homo sapiens |
| 5 | Knockdown of IGF-1R by plasmids with siRNA (si) against IGF-1R mRNA resulted in inhibition of proliferation of PC-3 cells and cell numbers did not differ when the si-IGF-1R groups (cells transfected with plasmids containing siRNA against IGF-1R mRNA) were treated or untreated with enterolactone. | 2,3-bis(3'-hydroxybenzyl)butyrolactone | insulin like growth factor 1 receptor | Homo sapiens |
| 6 | Knockdown of IGF-1R by plasmids with siRNA (si) against IGF-1R mRNA resulted in inhibition of proliferation of PC-3 cells and cell numbers did not differ when the si-IGF-1R groups (cells transfected with plasmids containing siRNA against IGF-1R mRNA) were treated or untreated with enterolactone. | 2,3-bis(3'-hydroxybenzyl)butyrolactone | insulin like growth factor 1 receptor | Homo sapiens |
| 7 | These results suggest that enterolactone suppresses proliferation and migration of prostate cancer cells, at least partially, through inhibition of IGF-1/IGF-1R signaling. | 2,3-bis(3'-hydroxybenzyl)butyrolactone | insulin like growth factor 1 receptor | Homo sapiens |