Pub. Date : 2009 Jun
PMID : 19176881
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Estradiol suppresses glutamatergic transmission to gonadotropin-releasing hormone neurons in a model of negative feedback in mice. | Estradiol | gonadotropin releasing hormone 1 | Mus musculus |
| 2 | The GnRH surge is initiated by a switch in estradiol action from negative to positive feedback. | Estradiol | gonadotropin releasing hormone 1 | Mus musculus |
| 3 | Estradiol signals critical for the surge are likely transmitted to GnRH neurons at least in part via estradiol-sensitive afferents. | Estradiol | gonadotropin releasing hormone 1 | Mus musculus |
| 4 | The diurnal removal of estradiol-induced suppression of AMPA/KA R-mediated glutamate transmission to GnRH neurons during positive feedback suggests that the primary role for estradiol-induced changes in glutamate transmission may be in mediating negative feedback. | Estradiol | gonadotropin releasing hormone 1 | Mus musculus |
| 5 | The diurnal removal of estradiol-induced suppression of AMPA/KA R-mediated glutamate transmission to GnRH neurons during positive feedback suggests that the primary role for estradiol-induced changes in glutamate transmission may be in mediating negative feedback. | Estradiol | gonadotropin releasing hormone 1 | Mus musculus |