PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19176881-0	2009	Estradiol suppresses glutamatergic transmission to gonadotropin-releasing hormone neurons in a model of negative feedback in mice.	Estradiol	0-9	gonadotropin releasing hormone 1	Mus musculus	51-81	
19176881-2	2009	The GnRH surge is initiated by a switch in estradiol action from negative to positive feedback.	Estradiol	43-52	gonadotropin releasing hormone 1	Mus musculus	4-8	
19176881-3	2009	Estradiol signals critical for the surge are likely transmitted to GnRH neurons at least in part via estradiol-sensitive afferents.	Estradiol	101-110	gonadotropin releasing hormone 1	Mus musculus	67-71	
19176881-10	2009	The diurnal removal of estradiol-induced suppression of AMPA/KA R-mediated glutamate transmission to GnRH neurons during positive feedback suggests that the primary role for estradiol-induced changes in glutamate transmission may be in mediating negative feedback.	Estradiol	23-32	gonadotropin releasing hormone 1	Mus musculus	101-105	
19176881-10	2009	The diurnal removal of estradiol-induced suppression of AMPA/KA R-mediated glutamate transmission to GnRH neurons during positive feedback suggests that the primary role for estradiol-induced changes in glutamate transmission may be in mediating negative feedback.	Estradiol	174-183	gonadotropin releasing hormone 1	Mus musculus	101-105