Pub. Date : 2008
PMID : 19172696
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The reduced folate carrier (RFC1) 80G > A and folate hydrolase 1 (FOLH1) 1561C > T polymorphisms and the risk of colorectal cancer: a nested case-referent study. | Folic Acid | replication factor C subunit 1 | Homo sapiens |
| 2 | In this nested case-referent study, we related two such polymorphisms, reduced folate carrier (RFC1) 80G > A and folate hydrolase 1 (FOLH1) 1561C > T, to the risk of colorectal cancer, taking into account pre-diagnostic plasma folate and total homocysteine concentrations and the MTHFR 677C > T polymorphism, which were analysed in a previous study. | Folic Acid | replication factor C subunit 1 | Homo sapiens |
| 3 | RESULTS: The RFC1 80A-allele was associated with reduced plasma folate and elevated plasma total homocysteine concentrations, but the result was statistically significant only for folate. | Folic Acid | replication factor C subunit 1 | Homo sapiens |
| 4 | RESULTS: The RFC1 80A-allele was associated with reduced plasma folate and elevated plasma total homocysteine concentrations, but the result was statistically significant only for folate. | Folic Acid | replication factor C subunit 1 | Homo sapiens |
| 5 | CONCLUSIONS: These findings suggest that although the RFC1 80G > A and FOLH1 1561C > T polymorphisms may influence folate status, they are not likely to have a major independent role in the development of colorectal cancer. | Folic Acid | replication factor C subunit 1 | Homo sapiens |