PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19172696-0 2008 The reduced folate carrier (RFC1) 80G > A and folate hydrolase 1 (FOLH1) 1561C > T polymorphisms and the risk of colorectal cancer: a nested case-referent study. Folic Acid 12-18 replication factor C subunit 1 Homo sapiens 28-32 19172696-2 2008 In this nested case-referent study, we related two such polymorphisms, reduced folate carrier (RFC1) 80G > A and folate hydrolase 1 (FOLH1) 1561C > T, to the risk of colorectal cancer, taking into account pre-diagnostic plasma folate and total homocysteine concentrations and the MTHFR 677C > T polymorphism, which were analysed in a previous study. Folic Acid 79-85 replication factor C subunit 1 Homo sapiens 95-99 19172696-4 2008 RESULTS: The RFC1 80A-allele was associated with reduced plasma folate and elevated plasma total homocysteine concentrations, but the result was statistically significant only for folate. Folic Acid 64-70 replication factor C subunit 1 Homo sapiens 13-17 19172696-4 2008 RESULTS: The RFC1 80A-allele was associated with reduced plasma folate and elevated plasma total homocysteine concentrations, but the result was statistically significant only for folate. Folic Acid 180-186 replication factor C subunit 1 Homo sapiens 13-17 19172696-9 2008 CONCLUSIONS: These findings suggest that although the RFC1 80G > A and FOLH1 1561C > T polymorphisms may influence folate status, they are not likely to have a major independent role in the development of colorectal cancer. Folic Acid 121-127 replication factor C subunit 1 Homo sapiens 54-58