Title : Elaboration, diversification and regulation of the Sir1 family of silencing proteins in Saccharomyces.

Pub. Date : 2009 Apr

PMID : 19171939






1 Functional Relationships(s)
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1 We propose that the functional specialization of Sir3, itself a paralog of Orc1, as a silencing protein was facilitated by the tandem duplication of the OIR domain in the Sir1 family, allowing distinct Sir1-Sir3 and Sir1-Orc1 interactions through OIR-BAH domain interactions. bis(5-amidino-2-benzimidazolyl)methane ketone hydrate chromatin-silencing protein SIR3 Saccharomyces cerevisiae S288C