Title : EGF promotes invasion by PANC-1 cells through Rac1/ROS-dependent secretion and activation of MMP-2.

Pub. Date : 2009 Feb 6

PMID : 19116140






1 Functional Relationships(s)
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1 Our results also indicate that signaling events downstream of EGF receptor involved PI3K- and Src-dependent activation of Rac1, which mediated the NADPH-generated reactive oxygen species responsible for MMP-2 secretion and activation. Reactive Oxygen Species epidermal growth factor receptor Homo sapiens