Title : Structural studies of human histone deacetylase 8 and its site-specific variants complexed with substrate and inhibitors.

Pub. Date : 2008 Dec 23

PMID : 19053282






1 Functional Relationships(s)
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1 Finally, the structure of H143A HDAC8 complexed with an intact acetylated tetrapeptide substrate molecule confirms the importance of D101 for substrate binding and reveals how Y306 and the active site zinc ion together bind and activate the scissile amide linkage of acetyllysine. Amides histone deacetylase 8 Homo sapiens