Pub. Date : 2009 Feb 10
PMID : 19028507
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibition of benzopyrene-diol-epoxide (BPDE)-induced bax and caspase-9 by cadmium: role of mitogen activated protein kinase. | 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide | caspase 9 | Homo sapiens |
| 2 | We observed that BPDE treatment also activates all three MAP kinases e.g. ERK1/2, p38 and JNK in HL-60 cells, and inhibition of BPDE-induced apoptosis by cadmium is associated with down-regulation of pro-apoptotic bax induction/caspase-9 activation and up-regulation of ERK phosphorylation, whereas p38 MAP kinase and c-Jun phosphorylation (indicative of JNK activation) remain unaffected. | 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide | caspase 9 | Homo sapiens |
| 3 | We observed that BPDE treatment also activates all three MAP kinases e.g. ERK1/2, p38 and JNK in HL-60 cells, and inhibition of BPDE-induced apoptosis by cadmium is associated with down-regulation of pro-apoptotic bax induction/caspase-9 activation and up-regulation of ERK phosphorylation, whereas p38 MAP kinase and c-Jun phosphorylation (indicative of JNK activation) remain unaffected. | 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide | caspase 9 | Homo sapiens |