Protein Name caspase 9
Organism Homo sapiens
Gene ID 842
Gene Symbol


UniProt P55211 (CASP9_HUMAN), F8VVS7 (F8VVS7_HUMAN)
Relationships Total Number of functionally related compound(s) : 1801
Total Number of Articles : 3140

caspase 9

Gene Summary

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1; this step is thought to be one of the earliest in the caspase activation cascade. This protein is thought to play a central role in apoptosis and to be a tumor suppressor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

  • caspase-9
  • ICE-like apoptotic protease 6
  • apoptotic protease MCH-6
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