PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19028507-0 2009 Inhibition of benzopyrene-diol-epoxide (BPDE)-induced bax and caspase-9 by cadmium: role of mitogen activated protein kinase. 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 40-44 caspase 9 Homo sapiens 62-71 19028507-4 2009 We observed that BPDE treatment also activates all three MAP kinases e.g. ERK1/2, p38 and JNK in HL-60 cells, and inhibition of BPDE-induced apoptosis by cadmium is associated with down-regulation of pro-apoptotic bax induction/caspase-9 activation and up-regulation of ERK phosphorylation, whereas p38 MAP kinase and c-Jun phosphorylation (indicative of JNK activation) remain unaffected. 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 17-21 caspase 9 Homo sapiens 228-237 19028507-4 2009 We observed that BPDE treatment also activates all three MAP kinases e.g. ERK1/2, p38 and JNK in HL-60 cells, and inhibition of BPDE-induced apoptosis by cadmium is associated with down-regulation of pro-apoptotic bax induction/caspase-9 activation and up-regulation of ERK phosphorylation, whereas p38 MAP kinase and c-Jun phosphorylation (indicative of JNK activation) remain unaffected. 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 128-132 caspase 9 Homo sapiens 228-237