Title : Mitochondrial dysfunction triggered by loss of HtrA2 results in the activation of a brain-specific transcriptional stress response.

Pub. Date : 2009 Mar

PMID : 19023330






1 Functional Relationships(s)
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1 We also show that loss of HtrA2 results in the accumulation of unfolded proteins in the mitochondria, defective mitochondrial respiration and enhanced production of reactive oxygen species that contribute to the induction of CHOP expression and to neuronal cell death. Oxygen DNA damage inducible transcript 3 Homo sapiens