Title : Antagonism of peripheral inflammation reduces the severity of status epilepticus.

Pub. Date : 2009 Feb

PMID : 19010416






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1 Since IL-1beta is an etiologic trigger for BBB breakdown and its serum elevation occurs before onset of SE early after LiCl and pilocarpine injections, we tested the hypothesis that intravenous administration of IL-1 receptor antagonists (IL-1ra) may prevent pilocarpine-induced seizures. Lithium Chloride interleukin 1 receptor antagonist Homo sapiens