| Protein Name | interleukin 1 receptor antagonist |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 3557 |
| Gene Symbol | IL1RN |
| UniProt | P18510 (IL1RA_HUMAN), A0A024R528 (A0A024R528_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
491
Total Number of Articles : 621 |
Description |
interleukin 1 receptor antagonist |
| Gene Summary |
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses, particularly in the acute phase of infection and inflammation. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Aug 2020] |
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