Pub. Date : 2009 Mar
PMID : 19005461
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Interindividual variation in the pharmacokinetics of Delta9-tetrahydrocannabinol as related to genetic polymorphisms in CYP2C9. | Dronabinol | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |
| 2 | The impact of the CYP2C9 polymorphism on the pharmacokinetics of orally administered 9-tetrahydrocannabinol (THC) was studied in 43 healthy volunteers. | Dronabinol | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |
| 3 | However, the median area under the curve of THC was threefold higher and that of 11-nor-9-carboxy-9-tetrahydrocannabinol was 70% lower in CYP2C9*3/*3 homozygotes than in CYP2C9*1/*1 homozygotes. | Dronabinol | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |
| 4 | CYP2C9*3 carriers also showed a trend toward increased sedation following administration of THC. | Dronabinol | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |
| 5 | Therefore, the CYP2C9*3 variant may influence both the therapeutic and adverse effects of THC. | Dronabinol | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |