PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19005461-0 2009 Interindividual variation in the pharmacokinetics of Delta9-tetrahydrocannabinol as related to genetic polymorphisms in CYP2C9. Dronabinol 53-80 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 120-126 19005461-1 2009 The impact of the CYP2C9 polymorphism on the pharmacokinetics of orally administered 9-tetrahydrocannabinol (THC) was studied in 43 healthy volunteers. Dronabinol 85-107 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 18-24 19005461-3 2009 However, the median area under the curve of THC was threefold higher and that of 11-nor-9-carboxy-9-tetrahydrocannabinol was 70% lower in CYP2C9*3/*3 homozygotes than in CYP2C9*1/*1 homozygotes. Dronabinol 44-47 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 138-144 19005461-4 2009 CYP2C9*3 carriers also showed a trend toward increased sedation following administration of THC. Dronabinol 92-95 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 0-6 19005461-5 2009 Therefore, the CYP2C9*3 variant may influence both the therapeutic and adverse effects of THC. Dronabinol 90-93 cytochrome P450 family 2 subfamily C member 9 Homo sapiens 15-21